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  1. Type 2 diabetes mellitus (T2DM) and hypothyroidism are two common endocrine diseases and the phenomenon that the prevalence of diabetes-related hypothyroidism shows a significant upward trend deserves further ...

    Authors: Jingyi Luo, Xiaoxia Wang, Li Yuan and Lixin Guo

    Citation: Clinical Epigenetics 2021 13:123

    Content type: Research

    Published on:

  2. Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor patient prognosis. We investigated how genomic distribution of accessible chromatin sites is altered during acquisition of c...

    Authors: John Gallon, Erick Loomis, Edward Curry, Nicholas Martin, Leigh Brody, Ian Garner, Robert Brown and James M. Flanagan

    Citation: Clinical Epigenetics 2021 13:122

    Content type: Research

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  3. The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiologic...

    Authors: Pamela R. Matías-García, Cavin K. Ward-Caviness, Laura M. Raffield, Xu Gao, Yan Zhang, Rory Wilson, Xīn Gào, Jana Nano, Andrew Bostom, Elena Colicino, Adolfo Correa, Brent Coull, Charles Eaton, Lifang Hou, Allan C. Just, Sonja Kunze…

    Citation: Clinical Epigenetics 2021 13:121

    Content type: Research

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  4. At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been proposed as a major factor in tumor initiation, progression, metastasis, and recurrence. CSCs are a subpopulation ...

    Authors: Saeedeh Keyvani-Ghamsari, Khatereh Khorsandi, Azhar Rasul and Muhammad Khatir Zaman

    Citation: Clinical Epigenetics 2021 13:120

    Content type: Review

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  5. ZNF445, as well as ZFP57, is involved in the postfertilization methylation maintenance of multiple imprinting-associated differentially methylated regions (iDMRs). Thus, ZNF445 pathogenic variants are predicted t...

    Authors: Masayo Kagami, Kaori Hara-Isono, Keiko Matsubara, Kazuhiko Nakabayashi, Satoshi Narumi, Maki Fukami, Yumiko Ohkubo, Hirotomo Saitsu, Shuji Takada and Tsutomu Ogata

    Citation: Clinical Epigenetics 2021 13:119

    Content type: Research

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  6. There are no prior reports that compare differentially methylated regions of DNA in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 pandemic using a shared epigenotyping platfor...

    Authors: Joseph Balnis, Andy Madrid, Kirk J. Hogan, Lisa A. Drake, Hau C. Chieng, Anupama Tiwari, Catherine E. Vincent, Amit Chopra, Peter A. Vincent, Michael D. Robek, Harold A. Singer, Reid S. Alisch and Ariel Jaitovich

    Citation: Clinical Epigenetics 2021 13:118

    Content type: Research

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  7. Mutations in the POLE gene result in an ultra-hypermutated phenotype in colorectal cancer (CRC); however, the molecular characterisation of epigenetic alterations remains unclear. We examined the genetic and epig...

    Authors: Takashi Kawai, Akihiro Nyuya, Yoshiko Mori, Takehiro Tanaka, Hiroaki Tanioka, Kazuya Yasui, Toshiaki Toshima, Fumitaka Taniguchi, Kunitoshi Shigeyasu, Yuzo Umeda, Toshiyoshi Fujiwara, Makoto Okawaki, Yoshiyuki Yamaguchi, Ajay Goel and Takeshi Nagasaka

    Citation: Clinical Epigenetics 2021 13:117

    Content type: Research

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  8. The human endometrium is a highly dynamic tissue whose function is mainly regulated by the ovarian steroid hormones estradiol and progesterone. The serum levels of these and other hormones are associated with ...

    Authors: Alejandra Monserrat Retis-Resendiz, Ixchel Nayeli González-García, Moisés León-Juárez, Ignacio Camacho-Arroyo, Marco Cerbón and Edgar Ricardo Vázquez-Martínez

    Citation: Clinical Epigenetics 2021 13:116

    Content type: Review

    Published on:

  10. Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease. Our previous studies demonstrated that the reg...

    Authors: Michele Zampieri, Maria Giulia Bacalini, Ilaria Barchetta, Stefania Scalea, Flavia Agata Cimini, Laura Bertoccini, Stefano Tagliatesta, Giovanna De Matteis, Giuseppe Zardo, Maria Gisella Cavallo and Anna Reale

    Citation: Clinical Epigenetics 2021 13:114

    Content type: Research

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  13. Worldwide, colorectal cancer (CRC) is a deadly disease whose death rate ranks second among cancers though its incidence ranks third. Early CRC detection is key and is associated with improved survival outcomes...

    Authors: Farah J. Nassar, Zahraa S. Msheik, Rihab R. Nasr and Sally N. Temraz

    Citation: Clinical Epigenetics 2021 13:111

    Content type: Review

    Published on:

  14. The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physica...

    Authors: Elina Sillanpää, Aino Heikkinen, Anna Kankaanpää, Aini Paavilainen, Urho M. Kujala, Tuija H. Tammelin, Vuokko Kovanen, Sarianna Sipilä, Kirsi H. Pietiläinen, Jaakko Kaprio, Miina Ollikainen and Eija K. Laakkonen

    Citation: Clinical Epigenetics 2021 13:110

    Content type: Research

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  17. Long-term stored serum is considered challenging for epigenomic analyses: as there are no cells, circulating DNA is scarce, and amplification removes epigenetic signals. Additionally, pre-analytical treatments...

    Authors: Marcin W. Wojewodzic, Magnus Leithaug, Marianne Lauritzen, Robert Lyle, Sofia Haglund, Carl-Johan Rubin, Philip A. Ewels, Tom Grotmol and Trine B. Rounge

    Citation: Clinical Epigenetics 2021 13:107

    Content type: Research

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  18. Methylation of DNA at CpG sites is an epigenetic modification and a potential modifier of disease risk, possibly mediating environmental effects. Currently, DNA methylation is commonly assessed using specific ...

    Authors: Cilla Söderhäll, Lovisa E. Reinius, Pertteli Salmenperä, Massimiliano Gentile, Nathalie Acevedo, Jon R. Konradsen, Björn Nordlund, Gunilla Hedlin, Annika Scheynius, Samuel Myllykangas and Juha Kere

    Citation: Clinical Epigenetics 2021 13:106

    Content type: Research

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  20. Definitive diagnosis of primary central nervous system lymphoma (PCNSL) requires invasive surgical brain biopsy, causing treatment delays. In this paper, we identified and validated tumor-specific markers that...

    Authors: Bradley M. Downs, Wanjun Ding, Leslie M. Cope, Christopher B. Umbricht, Wenge Li, Huihua He, Xiaokang Ke, Matthias Holdhoff, Chetan Bettegowda, Weiping Tao and Saraswati Sukumar

    Citation: Clinical Epigenetics 2021 13:104

    Content type: Research

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  21. Current risk models for renal cell carcinoma (RCC) based on clinicopathological factors are sub-optimal in accurately identifying high-risk patients. Here, we perform a head-to-head comparison of previously pu...

    Authors: S. C. Joosten, S. N. O. Odeh, A. Koch, N. Buekers, M. J. B. Aarts, M. M. L. L. Baldewijns, L. Van Neste, S. van Kuijk, L. J. Schouten, P. A. van den Brandt, V. C. Tjan-Heijnen, M. van Engeland and K. M. Smits

    Citation: Clinical Epigenetics 2021 13:103

    Content type: Research

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  22. DNA methylation profiling has facilitated and improved the classification of a wide variety of tumors of the central nervous system. In this study, we investigated the potential utility of DNA methylation prof...

    Authors: Sandra Ferreyra Vega, Thomas Olsson Bontell, Alba Corell, Anja Smits, Asgeir Store Jakola and Helena Carén

    Citation: Clinical Epigenetics 2021 13:102

    Content type: Research

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  23. Biological relevance of the major testis specific histone H2B variant (TH2B) in sperm is not fully understood. Studies in TH2A/TH2B double knockout male mice indicate its role in chromatin compaction and male ...

    Authors: Aniket Patankar, Rahul Gajbhiye, Suchitra Surve and Priyanka Parte

    Citation: Clinical Epigenetics 2021 13:101

    Content type: Research

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  24. The mechanisms of weight loss and metabolic improvements following bariatric surgery in skeletal muscle are not well known; however, epigenetic modifications are likely to contribute. The aim of our study was ...

    Authors: Luis A. Garcia, Samantha E. Day, Richard L. Coletta, Baltazar Campos, Tonya R. Benjamin, Eleanna De Filippis, James A. Madura II, Lawrence J. Mandarino, Lori R. Roust and Dawn K. Coletta

    Citation: Clinical Epigenetics 2021 13:100

    Content type: Research

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  25. A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to developing diabetic kidney disease (DKD), the most common cause globally of end-stage kidney disease (ESKD). Emerging evidence su...

    Authors: L. J. Smyth, J. Kilner, V. Nair, H. Liu, E. Brennan, K. Kerr, N. Sandholm, J. Cole, E. Dahlström, A. Syreeni, R. M. Salem, R. G. Nelson, H. C. Looker, C. Wooster, K. Anderson, G. J. McKay…

    Citation: Clinical Epigenetics 2021 13:99

    Content type: Research

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  26. In DNA methylation analyses like epigenome-wide association studies, effects in differentially methylated CpG sites are assessed. Two kinds of outcomes can be used for statistical analysis: Beta-values and M-valu...

    Authors: Jochen Kruppa, Miriam Sieg, Gesa Richter and Anne Pohrt

    Citation: Clinical Epigenetics 2021 13:98

    Content type: Methodology

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  27. Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especia...

    Authors: Linda Dieckmann, Marius Lahti-Pulkkinen, Tuomas Kvist, Jari Lahti, Peter E. DeWitt, Cristiana Cruceanu, Hannele Laivuori, Sara Sammallahti, Pia M. Villa, Sanna Suomalainen-König, Johan G. Eriksson, Eero Kajantie, Katri Raikkönen, Elisabeth B. Binder and Darina Czamara

    Citation: Clinical Epigenetics 2021 13:97

    Content type: Research

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  28. Although esophageal squamous cell carcinoma (ESCC)-oriented mechanism has been widely explored, the integrated action of histone deacetylase 2 (HDAC2), microRNA (miR)-503-5p and C-X-C motif chemokine 10 (CXCL1...

    Authors: Jindong Li, Chengyan Jin, Lihua Sun, Bin Wang, Peiyan Hua and Yan Zhang

    Citation: Clinical Epigenetics 2021 13:96

    Content type: Research

    Published on:

  29. Circulating folate, vitamin B12 and homocysteine concentrations during fetal development have been associated with health outcomes in childhood. Changes in fetal DNA methylation may be an underlying mechanism....

    Authors: Giulietta S. Monasso, Leanne K. Küpers, Vincent W. V. Jaddoe, Sandra G. Heil and Janine F. Felix

    Citation: Clinical Epigenetics 2021 13:95

    Content type: Research

    Published on:

  30. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Julia Stomper, Ruth Meier, Tobias Ma, Dietmar Pfeifer, Gabriele Ihorst, Nadja Blagitko-Dorfs, Gabriele Greve, Dennis Zimmer, Uwe Platzbecker, Anne Hagemeijer, Ingrid Schmitt-Graeff and Michael Lübbert

    Citation: Clinical Epigenetics 2021 13:94

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2021 13:77

  32. The Encyclopedia of DNA Elements (ENCODE) project has advanced our knowledge of the functional elements in the genome and epigenome. The aim of this article was to provide the comprehension about current resea...

    Authors: Young-Dan Cho, Woo-Jin Kim, Hyun-Mo Ryoo, Hong-Gee Kim, Kyoung-Hwa Kim, Young Ku and Yang-Jo Seol

    Citation: Clinical Epigenetics 2021 13:92

    Content type: Review

    Published on:

  33. Current non-invasive tests have limited sensitivities and lack capabilities of pre-operative risk stratification for bladder cancer (BC) diagnosis. We aimed to develop and validate a urine-based DNA methylatio...

    Authors: Weimei Ruan, Xu Chen, Ming Huang, Hong Wang, Jiaxin Chen, Zhixin Liang, Jingtong Zhang, Yanqi Yu, Shang Chen, Shizhong Xu, Tianliang Hu, Xia Li, Yuanjie Guo, Zeyu Jiang, Zhiwei Chen, Jian Huang…

    Citation: Clinical Epigenetics 2021 13:91

    Content type: Research

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  34. Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Early detection of CRC can significantly reduce its mortality rate. Current method of CRC diagnosis relies on the invasive endosco...

    Authors: Yunfeng Zhang, Qian Wu, Linhao Xu, Hong Wang, Xin Liu, Sihui Li, Tianliang Hu, Yanying Liu, Quanzhou Peng, Zhiwei Chen, Xianrui Wu and Jian-Bing Fan

    Citation: Clinical Epigenetics 2021 13:90

    Content type: Research

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  35. Aberrant DNA methylation has been firmly established as a factor contributing to the pathogenesis of colorectal cancer (CRC) via its capacity to silence tumour suppressor genes. However, the methylation status...

    Authors: Keke Shao, Weilin Pu, Jianfeng Zhang, Shicheng Guo, Fei Qian, Ingrid Glurich, Qing Jin, Yanyun Ma, Shaoqing Ju, Zhao Zhang and Weifeng Ding

    Citation: Clinical Epigenetics 2021 13:89

    Content type: Research

    Published on:

  36. Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly contributed to the characterization of the genetic driver alterations, further...

    Authors: Sarah Bazzocco, Higinio Dopeso, Águeda Martínez-Barriocanal, Estefanía Anguita, Rocío Nieto, Jing Li, Elia García-Vidal, Valentina Maggio, Paulo Rodrigues, Priscila Guimarães de Marcondes, Simo Schwartz Jr, Lauri A. Aaltonen, Alex Sánchez, John M. Mariadason and Diego Arango

    Citation: Clinical Epigenetics 2021 13:88

    Content type: Research

    Published on:

  38. The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylate...

    Authors: Alba Fernández-Sanlés, Sergi Sayols-Baixeras, Isaac Subirana, Mariano Sentí, S. Pérez-Fernández, Manuel de Castro Moura, Manel Esteller, Jaume Marrugat and Roberto Elosua

    Citation: Clinical Epigenetics 2021 13:86

    Content type: Research

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  39. Epigenetic mechanisms are important in aging and may be involved in late-life changes in cognitive abilities. We conducted an epigenome-wide association study of leukocyte DNA methylation in relation to level ...

    Authors: Ida K. Karlsson, Malin Ericsson, Yunzhang Wang, Juulia Jylhävä, Sara Hägg, Anna K. Dahl Aslan, Chandra A. Reynolds and Nancy L. Pedersen

    Citation: Clinical Epigenetics 2021 13:85

    Content type: Research

    Published on:

  40. Bladder cancer (BC) is the 5th most common cancer in the USA. Non-muscle invasive bladder cancer represents about 70% of all cases and has generally a favorable outcome. However, recurrence rates as high as 60...

    Authors: Paolo Piatti, Yap Ching Chew, Michiko Suwoto, Taikun Yamada, Benjamin Jara, Xi-Yu Jia, Wei Guo, Saum Ghodoussipour, Siamak Daneshmand, Hamed Ahmadi, Jeffrey Rice, Jeffrey Bhasin, Faith Holloway, Yvonne Tsai, Yoshitomo Chihara and Gangning Liang

    Citation: Clinical Epigenetics 2021 13:84

    Content type: Research

    Published on:

  41. Epigenetic (“above genetics”) modifications can alter the gene expression without altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA methylation, histone methylation, histone acet...

    Authors: Ning Jin, Tiffany L. George, Gregory A. Otterson, Claire Verschraegen, Haitao Wen, David Carbone, James Herman, Erin M. Bertino and Kai He

    Citation: Clinical Epigenetics 2021 13:83

    Content type: Review

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  42. Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate pre...

    Authors: Kristine L. Haftorn, Yunsung Lee, William R. P. Denault, Christian M. Page, Haakon E. Nustad, Robert Lyle, Håkon K. Gjessing, Anni Malmberg, Maria C. Magnus, Øyvind Næss, Darina Czamara, Katri Räikkönen, Jari Lahti, Per Magnus, Siri E. Håberg, Astanand Jugessur…

    Citation: Clinical Epigenetics 2021 13:82

    Content type: Research

    Published on:

  43. Eosinophilic esophagitis (EoE) is a leading cause of dysphagia and food impaction in children and adults. The diagnosis relies on histological examination of esophageal mucosal biopsies and requires the presen...

    Authors: Caterina Strisciuglio, Felicity Payne, Komal Nayak, Marialuisa Andreozzi, Alessandra Vitale, Erasmo Miele and Matthias Zilbauer

    Citation: Clinical Epigenetics 2021 13:81

    Content type: Short report

    Published on:

  44. Colonoscopy and the fecal immunochemical test (FIT) are currently the most widely used screening modalities for colorectal cancer (CRC), however, both with their own limitations. Here we aim to identify and va...

    Authors: Glenn Rademakers, Maartje Massen, Alexander Koch, Muriel X. Draht, Nikkie Buekers, Kim A. D. Wouters, Nathalie Vaes, Tim De Meyer, Beatriz Carvalho, Gerrit A. Meijer, James G. Herman, Kim M. Smits, Manon van Engeland and Veerle Melotte

    Citation: Clinical Epigenetics 2021 13:80

    Content type: Research

    Published on:

  45. Diagnostic biomarkers for detecting chronic obstructive pulmonary disease (COPD) in acute coronary syndrome (ACS) patients are not available. SERPINA1, coding for the most potent circulating anti-inflammatory pro...

    Authors: John Charles Rotondo, Giorgio Aquila, Lucia Oton-Gonzalez, Rita Selvatici, Paola Rizzo, Monica De Mattei, Rita Pavasini, Mauro Tognon, Gianluca Calogero Campo and Fernanda Martini

    Citation: Clinical Epigenetics 2021 13:79

    Content type: Research

    Published on:

  46. Prenatal symptoms of depression (PND) and anxiety affect up to every third pregnancy. Children of mothers with mental health problems are at higher risk of developmental problems, possibly through epigenetic m...

    Authors: Theodora Kunovac Kallak, Emma Bränn, Emma Fransson, Åsa Johansson, Susanne Lager, Erika Comasco, Robert Lyle and Alkistis Skalkidou

    Citation: Clinical Epigenetics 2021 13:78

    Content type: Research

    Published on:

  47. Mutations in the EZH2 gene are recurrently found in patients with myeloid neoplasms and are associated with a poor prognosis. We aimed to characterize genetic and epigenetic alterations of EZH2 in 58 patients (51...

    Authors: Julia Stomper, Ruth Meier, Tobias Ma, Dietmar Pfeifer, Gabriele Ihorst, Nadja Blagitko-Dorfs, Gabriele Greve, Dennis Zimmer, Uwe Platzbecker, Anne Hagemeijer, Ingrid Schmitt-Graeff and Michael Lübbert

    Citation: Clinical Epigenetics 2021 13:77

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2021 13:94

  48. Dysregulation of thymic stromal lymphopoietin (TSLP) expressions is linked to asthma and allergic disease. Exposure to phthalate esters, a widely used plasticizer, is associated with respiratory and allergic m...

    Authors: Wan-Ru Wang, Nai-Tzu Chen, Nai-Yun Hsu, I-Ying Kuo, Hsin-Wen Chang, Jiu-Yao Wang and Huey-Jen Su

    Citation: Clinical Epigenetics 2021 13:76

    Content type: Research

    Published on:

  49. The integration of different layers of omics information is an opportunity to tackle the complexity of cardiovascular diseases (CVD) and to identify new predictive biomarkers and potential therapeutic targets....

    Authors: Guillermo Palou-Márquez, Isaac Subirana, Lara Nonell, Alba Fernández-Sanlés and Roberto Elosua

    Citation: Clinical Epigenetics 2021 13:75

    Content type: Research

    Published on:

  50. Prenatal smoking exposure has been associated with childhood attention-deficit/hyperactivity disorder (ADHD). However, the mechanism underlying this relationship remains unclear. We assessed whether DNA methyl...

    Authors: Kunio Miyake, Chihiro Miyashita, Atsuko Ikeda-Araki, Ryu Miura, Sachiko Itoh, Keiko Yamazaki, Sumitaka Kobayashi, Hideyuki Masuda, Tadao Ooka, Zentaro Yamagata and Reiko Kishi

    Citation: Clinical Epigenetics 2021 13:74

    Content type: Research

    Published on:

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Clinical Epigenetics

ISSN: 1868-7083

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